Cerivastatin Sodium

Indications
 Oral
Hypercholesterolaemia
Adult: Initially, 100 mcg once daily at night adjusted to 100 mcg increments at min of 4-wk intervals. Max dose: 300 mcg daily.
Renal impairment: Dose reduction may be necessary.

Special Populations: Max dose for patients with severe renal impairment is 200 mcg once daily.
Contraindications
 Hypersensitivity; acute liver disease or unexplained increase in serum-aminotransferase concentrations; porphyria. Pregnancy.
Warnings / Precautions
 Severe renal impairment. Monitor liver function.
Adverse Reactions
 GI disturbances, dysgeusia; headache, dizziness, insomnia; rashes; blurred vision.
Potentially Fatal: Hepatitis, pancreatitis, rhabdomyolysis.
Drug Interactions
 Concurrent admin with immunosuppressants, fibric acid derivatives, nicotinic acid increase risk of myopathy. Increased bleeding with anticoagulants. Raised plasma conc with mibefradil.
See Below for More cerivastatin sodium Drug Interactions
Mechanism of Actions
 Cerivastatin inhibits HMG CoA reductase, the rate-limiting enzyme in cholesterol synthesis. It reduces low-density lipoproteins (LDL) and very low-density lipoproteins (VLDL), but increases high-density lipoproteins (HDL) by stimulating an increase in LDL receptors on hepatocyte membranes thus increasing LDL clearance.
Absorption: Rapid and almost complete from the GIT (oral).
Distribution: Protein-binding: 99%
Metabolism: Hepatic; converted to active metabolites.
Excretion: Urine and faeces (as metabolites); 2-3 hrs (elimination half-life).
Storage Conditions
 Oral: Store below 25°C.
Storage
 Oral: Store below 25°C.
Available As
  • Cerivastatin Sodium 0.4 mg
  • Cerivastatin Sodium 0.8 mg

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