Ceftriaxone

Indications
Intramuscular
Uncomplicated gonorrhoea
Adult: 250 mg as a single dose.
CrCl (ml/min)Dosage Recommendation
<10Max: 2 g daily.

Intramuscular
Prophylaxis of secondary meningococcal meningitis
Adult: 250 mg as a single dose.
Child: 125 mg as a single dose.
Max Dosage:
CrCl (ml/min)Dosage Recommendation
<10Max: 2 g daily.

Parenteral
Susceptible infections
Adult: 1-2 g daily as a single or in 2 divided doses given as deep IM inj or slow IV inj over 2-4 minutes or as infusion over at least 30 minutes, increased to 4 g daily in severe infections.
Child: <50 kg: 25-50 mg/kg once daily increased to 80 mg/kg in severe infections. Doses >50 mg/kg should be given as IV infusion. IV infusion in neonates should be given over 60 min. Max dose (neonates): 50 mg/kg/day.
CrCl (ml/min)Dosage Recommendation
<10Max: 2 g daily.

Parenteral
Prophylaxis of surgical infections
Adult: 1 g as a single dose given 0.5-2 hr prior to surgery via deep IM inj or slow IV inj over at least 2-4 minutes or IV infusion over at least 30 minutes. A 2 g dose is recommended for colorectal surgery.
CrCl (ml/min)Dosage Recommendation
<10Max: 2 g daily.

Intravenous
Typhoid fever
Adult: 2 g once daily for 14 days.
CrCl (ml/min)Dosage Recommendation
<10Max: 2 g daily.


Special Populations: Reduce dose in patients with severe renal impairment and those with both renal and hepatic impairment.

Incompatibility: Y-site incompatibility: Alatrofloxacin, amphotericin B cholesteryl sulfate complex, pentamidine, parenteral nutrition solutions (containing calcium), amsacrine, azithromycin, calcium, filgrastim, fluconazole, Hartmann's solution, labetalol, vinorelbine. Admixture incompatibility: Aminophylline, amsacrine, fluconazole, linezolid, calcium, clindamycin, theophylline.
Contraindications
Hypersensitivity to cephalosporins; hyperbilirubinaemic neonates. Do not use calcium or calcium-containing solutions or products with or within 48 hr of ceftriaxone administration due to risk of calcium-ceftriaxone precipitate formation.
Warnings / Precautions
History of penicillin allergy; severe renal impairment; pregnancy and lactation; superinfection.
Adverse Reactions
Superinfection; anaphylaxis; diarrhoea; local reactions; blood dyscrasias; rash, fever, pruritus; elevated transaminases and alkaline phosphatase; leucopenia, neutropenia.
Potentially Fatal: Pseudomembranous colitis; nephrotoxicity.
Drug Interactions
Disulfiram-like reaction with alcohol.
Potentially Fatal: Nephrotoxicity with aminoglycosides and furosemide.
See Below for More ceftriaxone Drug Interactions
Lab Interactions
May interfere with urinary glucose test. False-positive Coomb's test.
Mechanism of Actions
Ceftriaxone binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Absorption: Peak plasma concentrations after 2 hr (IM).
Distribution: Distributed widely into body tissues and fluids; CSF (therapeutic concentrations). Crosses the placenta and enters breast milk; bile (high concentrations). Protein-binding: 85-95%.
Excretion: Via the urine (40-65% as unchanged); via the bile to the faeces (remainder as unchanged and microbiologically inactive compounds); 6-9 hr (elimination half-life).
Storage Conditions
Intramuscular: Store below 25°C. Intravenous: Store below 25°C. Parenteral: Store at 25°C.
ATC Classification
J01DD04 - ceftriaxone ; Belongs to the class of third-generation cephalosporins. Used in the systemic treatment of infections.
Storage
Intramuscular: Store below 25°C. Intravenous: Store below 25°C. Parenteral: Store at 25°C.
Available As
  • Ceftriaxone 1 gm
  • Ceftriaxone Sodium 1 gm
  • Ceftriaxone Sodium 1000 mg
  • Ceftriaxone 1000 mg
  • Sterlie Ceftriaxone 1000 mg
  • Ceftriaxone Sodium 125 mg
  • Ceftriaxone 125 mg
  • Ceftriaxone 1250 mg
  • Ceftriaxone Sodium 2 gm
  • Ceftriaxone 200 mg
  • Ceftriaxone Sodium 200 mg
  • Ceftriaxone 2000 mg
  • Ceftriaxone Sodium 2000 mg
  • Ceftriaxone Sodium 250 mg
  • Sterlie Ceftriaxone 250 mg
  • Ceftriaxone 250 mg
  • Ceftriaxone 50 mg
  • Sterlie Ceftriaxone 500 mg
  • Ceftriaxone Sodium 500 mg
  • Ceftriaxone 500 mg
  • Ceftriaxone Sodium 750 mg
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    Ceftriaxone Containing Brands

    Click on Prescription information to see Indications ( Uses ), Contraindications, Prescription information of respective Constituents.

    Brand Name Manufacturer Unit/Price Package unit/Price Constituents/Unit
    Injection Ceftrisone (1000 mg) Alcare (Akums Drugs Pharmaceuticals Ltd.) 1 Vial
    ₹ 10.00
    1 Vial
    ₹ 10.00
  • More Information Ceftriaxone Sodium 1000 mg
  • See Brands having above combination
    Injection Ceftrisone (250 mg) Alcare (Akums Drugs Pharmaceuticals Ltd.) 1 Vial
    ₹ 5.00
    1 Vial
    ₹ 5.00
  • More Information Ceftriaxone Sodium 250 mg
  • See Brands having above combination
    Injection Ceftrisone (500 mg) Alcare (Akums Drugs Pharmaceuticals Ltd.) 1 Vial
    ₹ 6.00
    1 Vial
    ₹ 6.00
  • More Information Ceftriaxone Sodium 500 mg
  • See Brands having above combination
    Tablet Tu Xone (1000 mg) Tuttsan Pharma Pvt Ltd. 1 Tablet
    ₹ 7.90
    10 Tablet
    ₹ 79.00
  • More Information Ceftriaxone 1000 mg
  • See Brands having above combination
    Tablet Tu Xone (250 mg) Tuttsan Pharma Pvt Ltd. 1 Tablet
    ₹ 2.60
    10 Tablet
    ₹ 26.00
  • More Information Ceftriaxone 250 mg
  • See Brands having above combination
    Tablet Tu Xone (500 mg) Tuttsan Pharma Pvt Ltd. 1 Tablet
    ₹ 4.80
    10 Tablet
    ₹ 48.00
  • More Information Ceftriaxone 500 mg
  • See Brands having above combination
    Injection Yoncef (1000+500) Pure Win Labs Pvt. Ltd. 1 Vial
    ₹ 7.81
    1 Vial
    ₹ 7.81
  • More Information Sulbactam 500 mg
  • More Information Ceftriaxone 1000 mg
  • See Brands having above combination
    Injection Yoncef (250+125) Pure Win Labs Pvt. Ltd. 1 Vial
    ₹ 1.80
    1 Vial
    ₹ 1.80
  • More Information Ceftriaxone 250 mg
  • More Information Sulbactam 125 mg
  • See Brands having above combination
    Injection Wyceft (1000 mg) Vostok & Wilcure Remedies 1 Vial
    ₹ 8.90
    1 Vial
    ₹ 8.90
  • More Information Ceftriaxone Sodium 1000 mg
  • See Brands having above combination
    Injection Wyceft (250 mg) Vostok & Wilcure Remedies 1 Vial
    ₹ 1.32
    1 Vial
    ₹ 1.32
  • More Information Ceftriaxone 250 mg
  • See Brands having above combination
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    Ceftriaxone is used in following diseases

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    Drug - Drug Interactions of Ceftriaxone
    Interaction
    Moderate, Consider therapy modification Calcium chloride vs CefTRIAXone
    Moderate, Consider therapy modification Calcium acetate vs CefTRIAXone
    Moderate, Consider therapy modification Calcium gluconate vs CefTRIAXone
    Minor, Monitor Therapy Ceftriaxone vs Vitamin K Antagonists (eg, warfarin)
    Moderate, Consider therapy modification Ceftriaxone vs Typhoid Vaccine
    Moderate, Consider therapy modification Ceftriaxone vs Ringer’s Injection (Lactated)
    Minor, Monitor Therapy Ceftriaxone vs Probenecid
    Moderate, Consider therapy modification Ceftriaxone vs Calcium Salts (Intravenous)
    Major, Avoid combination Ceftriaxone vs BCG
    Moderate, Consider therapy modification Aluminum sulfate calcium acetate vs CefTRIAXone