Ceftizoxime

Indications
 Parenteral
Susceptible infections
Adult: 1-2 g every 8-12 hr given as deep IM or slow IV Inj over 3-5 min, increased to 2-4 g IV every 8 hr in severe infections. Max dose: 2 g every 4 hr.
Child: >6 mth: 50 mg/kg every 6-8 hr.
Renal impairment: Loading dose: 0.5-1 g. Maintenance dose: According to CrCl.
CrCl (ml/min)Dosage Recommendation
50-790.5-1.5 g every 8 hr.
5-490.25-1 g every 12 hr.
<50.25-0.5 g every 24 hr or 0.5-1 g every 48 hr, after dialysis.

Parenteral
Uncomplicated urinary tract infections
Adult: 0.5 g every 12 hr.
Renal impairment: Loading dose: 0.5-1 g. Maintenance dose: According to CrCl.
CrCl (ml/min)Dosage Recommendation
50-790.5-1.5 g every 8 hr.
5-490.25-1 g every 12 hr.
<50.25-0.5 g every 24 hr or 0.5-1 g every 48 hr, after dialysis.

Intramuscular
Uncomplicated gonorrhoea
Adult: 1 g as a single dose.

Special Populations: Renal impairment: 0.5-1 g loading dose followed by maintenance dose adjusted according to the patient's creatinine clearance. CrCl: 50-79 mL/min: 0.5-1.5 g every 8 hrs; 5-49 mL/min: 0.25-1 g every 12 hrs; <5 mL/min: 0.25-0.5 g every 24 hrs or 1 g every 48 hrs after dialysis.
Contraindications
 Hypersensitivity to cephalosporins.
Warnings / Precautions
 Hypersensitivity to penicillins; severe renal impairment; pregnancy, lactation.
Adverse Reactions
 Burning; rash, pruritus, fever; anorexia, nausea, vomiting, diarrhoea; rarely neutropaenia, leucopaenia, thrombocytopaenia. Transient elevations of transaminases (SGOT and SGPT) and alkaline phosphatase, transient rise in BUN and creatinine.
Potentially Fatal: Anaphylactoid reactions, nephrotoxicity, pseudomembranous colitis,
Drug Interactions
 Renal clearance reduced with probenecid.
Potentially Fatal: Increased risk of nephrotoxicity with aminoglycosides and furosemide.
See Below for More ceftizoxime Drug Interactions
Lab Interactions
 False-positive for urine glucose and Coomb's test. False-positive serum or creatinine with Jaffe reaction.
Mechanism of Actions
 Ceftizoxime binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Absorption: Peak plasma concentrations after 1 hr.
Distribution: Distributed widely into body tissues and fluids; CSF (therapeutic concentrations). Crosses the placenta and enters the breast milk (low concentrations). Protein-binding: 30%
Excretion: Via the urine within 24 hrs by tubular and glomerular filtration (as unchanged); removed by dialysis. 1.7 hrs (elimination half-life).
Storage Conditions
 Intramuscular: Store at 15-30°C. Parenteral: Store at 15-30°C.
ATC Classification
 J01DD07 - ceftizoxime ; Belongs to the class of third-generation cephalosporins. Used in the systemic treatment of infections.
Storage
 Intramuscular: Store at 15-30°C. Parenteral: Store at 15-30°C.
Available As
  • Ceftizoxime 1000 mg
  • Ceftizoxime 250 mg

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