Respiratory tract infections, Urinary tract infections
Adult: As dihydrate: 400 mg once daily.
Child: >6 mth and ≤45 kg: 9 mg/kg/day as a single dose.
CrCl (ml/min)Dosage Recommendation
30-49200 mg once daily.
5-29100 mg once daily.

Special Populations: Moderate to severe renal impairment: CrCl 30-49 mL/min: 200 mg once daily; 5-29 mL/min: 100 mg once daily.
Hypersensitivity to cephalosporins.
Warnings / Precautions
Hypersensitivity to penicillins; renal impairment; Porphyria. Monitor renal and haematologic status.
Adverse Reactions
Nausea; vomiting; diarrhoea; hypersensitivity reactions; nephrotoxicity; convulsions; CNS toxicity; hepatic dysfunction; haematologic disorders; pain at Inj site (IM); thrombophloebitis (IV infusion); superinfection with prolonged use. Headache.
Potentially Fatal: Pseudomembranous colitis.
Drug Interactions
Renal excretion inhibited by probenecid. Bacteriostatic antibacterials.
Potentially Fatal: Nephrotoxic drug eg. aminoglycoside may increase risk of kidney damage. Enhanced nephrotoxicity with a loop diuretic.
See Below for More ceftibuten Drug Interactions
Lab Interactions
Positive direct antiglobulin Coombs' test; falsely high values with Jaffe method of measuring creatinine concentrations; +ve reactions for false glucose using copper-reduction reactions; transient increases in liver enzyme values.
Mechanism of Actions
Ceftibuten inhibits bacterial cell wall synthesis. It is stable to hydrolysis by many β-lactamases and has greater activity than 1st or 2nd generation cephalosporins against gm-ve bacteria. It is less active in vitro than cefexime against S. pneumoniae.
Absorption: Rapidly absorbed from the GI tract after oral admin.
Distribution: 65-77% bound to plasma proteins.
Excretion: Plasma half-life: 2.0-2.3 hr; prolonged in renal impairment. Mainly in the urine and faeces.
Cap: May be taken with or without food.
Susp: Should be taken on an empty stomach. (Take 2 hr before or 1 hr after meals.)
ATC Classification
J01DD14 - ceftibuten ; Belongs to the class of third-generation cephalosporins. Used in the systemic treatment of infections.
Available As
  • Ceftibuten 400 mg
  • Ceftibuten 90 mg
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