Indications |
Parenteral Susceptible infections Adult: As sodium: 2-4 g daily in 2 divided doses, increased to 12 g daily in 2-4 divided doses for severe infections given as deep IM or IV infusion. Renal impairment: With liver impairment: 1-2 g daily. Hepatic impairment: Max dose for liver impairment or biliary obstruction: 4 g daily. Special Populations: Max dose for liver impairment or biliary obstruction: 4 g daily; liver and kidney impairment: 1-2 g daily. |
Contraindications |
Hypersensitivity to cephalosporin. |
Warnings / Precautions |
History of penicillin allergy; renal or hepatic impairment; pregnancy, lactation; cystic fibrosis. |
Adverse Reactions |
Skin rash, urticaria; eosinophilia, diarrhoea, nausea, vomiting; phloebitis; hypoprothrombinaemia; superinfection. Potentially Fatal: Neuromuscular hypersensitivity; nephrotoxicity. |
Drug Interactions |
Disulfiram-like reaction with alcohol. Potentiates anticoagulants. Potentially Fatal: Enhances nephrotoxicity by aminoglycosides and furosemide. See Below for More cefoperazone Drug Interactions |
Mechanism of Actions |
Cefoperazone binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death. Distribution: Widely distributed into body tissues and fluids; poor CSF penetration. Crosses the placenta and enters breast milk (low concentrations); bile (high concentrations). Protein-binding: 82-93% Excretion: Mainly via the bile. Via the urine within 12-24 hrs by glomerular filtration (30% as unchanged); proportion may be increased in hepatic or biliary disease. |
Storage Conditions |
Parenteral: Store below 25°C. |
ATC Classification |
J01DD12 - cefoperazone ; Belongs to the class of third-generation cephalosporins. Used in the systemic treatment of infections. |
Storage |
Parenteral: Store below 25°C. |
Available As |
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Cefoperazone
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Cefoperazone Containing Brands
Cefoperazone is used in following diseases
Drug - Drug Interactions of Cefoperazone
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