Carbimazole

Indications
 Oral
Hyperthyroidism, Adjunct to radio-iodine therapy, Grave's disease, Preparation for thyroidectomy
Adult: Initially, 20-60 mg daily as a single or divided dose, reduced gradually once euthyroidism is achieved. Maintenance: 5-15 mg daily for at least 1 yr or 18 mth.
Child: 4-12 yr: Initially, 15 mg daily.
Contraindications
 Hyperthyroidism due to nodular goitre.
Warnings / Precautions
 Liver diseases, pregnancy, lactation.
Adverse Reactions
 Mild leucopaenia, sore throat, mouth ulcers, fever, bruising, malaise; rarely cholestatic jaundice; nephrotic syndrome. Nausea, loss of taste, headache, arthralgia, alopoecia.
Potentially Fatal: Agranulocytosis, aplastic anaemia, hypoprothrombinaemia, neutropaenia; hypothyroidism and goitre.
Drug Interactions
 Potentially Fatal: Increased sensitivity to warfarin in hyperthyroidism and careful control required as patient is rendered euthyroid.
See Below for More carbimazole Drug Interactions
Mechanism of Actions
 Carbimazole is metabolised to methimazole which is responsible for its antithyroid action. It blocks the production of thyroid hormones by inhibiting thyroid peroxidase.
Absorption: Rapid from the GIT (oral); peak plasma concentrations after 1-2 hrs.
Distribution: High concentrations in the thyroid gland; crosses the placenta; enters breast milk.
Metabolism: Hepatic; converted to methimazole.
Excretion: Urine (<12% unchanged drug); 3-6 hrs (elimination half-life).
Administration
 May be taken with or without food. (Take consistently w/ or w/o meals.)
Storage Conditions
 Oral: Store below 25°C.
ATC Classification
 H03BB01 - carbimazole ; Belongs to the class of sulfur-containing imidazole derivative agents. Used in the management of thyroid diseases.
Storage
 Oral: Store below 25°C.
Available As
  • Carbimazole 10 mg
  • Carbimazole 100 mg
  • Carbimazole 20 mg
  • Carbimazole 5 mg

    • Subscribe for latest updates

    Subscribe to our e-mail newsletter to receive updates.

    No comments yet.

    Post Review about Carbimazole


    Carbimazole Containing Brands

    We are Developing Our database, More results coming soon.

    Carbimazole is used in following diseases

    We are Developing Our database, More results coming soon.

    Drug - Drug Interactions of Carbimazole

    We are Developing Our database, More results coming soon.