Carbenicillin

Indications
 Oral
Urinary tract infections
Adult: 382-764 mg every 6 hr.
CrCl (ml/min)Dosage Recommendation
10-50382-764 mg every 12-24 hr.
<10Not recommended.

Oral
Prostatitis
Adult: 764 mg every 6 hr.
CrCl (ml/min)Dosage Recommendation
10-50382-764 mg every 12-24 hr.
<10Not recommended.


Special Populations: Dosing interval in patients with renal impairment: CrCl 10-50 mL/min: 382-764 mg every 12-24 hrs; <10 mL/min: 382-764 mg every 24-48 hrs.
Contraindications
 Hypersensitivity.
Warnings / Precautions
 Restricted sodium diet. Severely impaired renal function or heart failure. Avoid contact, skin sensitisation may occur. Monitor serum potassium concentration, renal and haematological status. Spirochete infections particularly syphilis; suprainfection with penicillin-resistant organisms with prolonged use; avoid intrathecal route.
Adverse Reactions
 Pain at inj site and phloebitis; electrolyte disturbances; dose-dependent coagulation defect; purpura and haemorrhage; hypersensitivity reactions including uticaria; fever; joint pains; rashes; angioedema; serum sickness-like reactions; haemolytic anaemia; interstitial nephritis; neutropenia; thrombocytopenia; CNS toxicity including convulsions; diarrhoea; antibiotic-associated colitis.
Potentially Fatal: Anaphylaxis.
Drug Interactions
 Probenecid prolongs T1/2 of carbenicillin. Bacteriostatic drugs e.g. chloramphenicol, tetracyclines; other antibacterials; anticoagulants.
See Below for More carbenicillin Drug Interactions
Lab Interactions
 May interfere with diagnostic tests for urinary glucose using copper sulfate, direct Coomb's test, and test for urinary or serum proteins. May interfere with diagnostic tests that use bacteria.
Mechanism of Actions
 Carbenicillin has an extended spectrum of activity against gm-ve bacteria. It is used in the treatment of infections caused by P. aeruginosa and non-penicillinase-producing strains of Proteus spp. Antimicrobial activity can be enhanced by aminoglycosides. It inhibits final cross-linking stage of peptidoglycan production by binding and inactivating transpeptidases on the inner surface of the bacterial cell membrane thus inhibiting bacterial cell wall synthesis.
Absorption: Not absorbed from GI tract.
Distribution: 50% bound to plasma proteins.
Excretion: half-life about 1-1.5 hr, increased in renal impairment. Excreted mainly by renal tubular secrettion and glomerular filtration.
Administration
 Should be taken on an empty stomach. (Preferably taken on an empty stomach 1 hr before or 2 hr after meals.)
ATC Classification
 J01CA03 - carbenicillin ; Belongs to the class of penicillins with extended spectrum. Used in the systemic treatment of infections.
Available As
  • Carbenicillin 1000 mg
  • Carbenicillin 5000 mg

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