Calcium Acetate

Indications
 Oral
Hyperphosphataemia
Adult: Initially 3-4 g daily. Usual range: 6-12 g daily. To control hyperphosphataemia in chronic renal failure Initially 1.334 g (338 mg of calcium). May increase dosage gradually according to serum phosphate conc, provided hypercalcaemia does not occur.
Warnings / Precautions
 Patients undergoing chronic hemodialysis. Renal impairment, diseases associated with hypercalcaemia such as sarcoidosis & some malignancies. Avoid in patients with calcium renal calculi or a history of renal calculi.
Adverse Reactions
 GI irritations. Excessive amounts may lead to hypercalcaemia.
Drug Interactions
 Tetracycline antibiotics, thiazide diuretics, vit D, corticosteroids, bisphosphonates, fluoride, some fluoroquinolones.
See Below for More calcium acetate Drug Interactions
Food Interactions
 Bran.
Mechanism of Actions
 Sequesters phosphate in the intestine by forming insoluble phosphates that are excreted faecally, thus reducing serum phosphate conc & secondary hyperparathyroidism.
Absorption: Mainly from the small intestine. 1,25-Dihydroxycholecalciferol (calcitriol), a metabolite of vit D, enhances absorption.
Distribution: Crosses the placenta & distributes into breast milk.
Excretion: Excess calcium is mainly excreted renally. Unabsorbed calcium is eliminated in the faeces, secreted in bile & pancreatic juice. Small amounts are lost in the sweat, skin, hair & nails.
Administration
 Should be taken with food.
Available As
  • calcium acetate 435 mg
  • Calcium Acetate 667 mg

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