Calcitonin

Indications
 Nasal
Postmenopausal osteoporosis
Adult: 200 units daily, alternating nostrils everyday.
Renal impairment: Dosage reduction may be required.
Parenteral
Paget's disease of bone
Adult: Initial dose: 100 units SC/IM daily. Maintenance regimen: 50 units SC/IM 3 times wkly to 100 units daily in patients with serious bone deformity or neurologic involvement.
Renal impairment: Dosage reduction may be required.
Parenteral
Adjunct in hypercalcaemia
Adult: 100 units every 6-8 hr by SC/IM inj. Adjust dose according to response. In severe cases, IV infusion up to 10 units/kg can be given over 6 hr. Max: 400 units every 6-8 hr.
Renal impairment: Dosage reduction may be required.
Parenteral
Postmenopausal osteoporosis
Adult: 100 units daily or every other day by SC/IM Inj together with calcium and vitamin D supplements.
Renal impairment: Dosage reduction may be required.
Parenteral
Bone pain due to malignant neoplasms
Adult: 200 units 4 times daily or 400 units bid for up to 48 hr by SC/IM inj.
Renal impairment: Dosage reduction may be required.
Intravenous
Emergency treatment of hypercalcaemia
Adult: 5-10 units/kg daily in 500 ml of 0.9% sodium chloride by slow IV infusion over 6 hr.
Renal impairment: Dosage reduction may be required.
Contraindications
 Hypersensitivity.
Warnings / Precautions
 Prior intradermal test preferably done. Children <18 yr, renal impairment. Pregnancy, lactation.
Adverse Reactions
 Nausea, vomiting, tingling of hands; Inj site inflammatory reactions, rashes, facial flushing, bronchospasm, headache, unusual taste, abdominal pain, anorexia. Nasal: Local irritation, ulceration, rhinitis, sinusitis, epistaxis.
Potentially Fatal: Anaphylactic shock.
Overdose Reactions
 May cause nausea and vomiting. Treatment may include parenteral admin of calcium.
Drug Interactions
 Concurrent use with digitalis, mithramycin, or biphosphonate resorption inhibitors calls for dosage adjustments of these drugs.
See Below for More calcitonin, salmon Drug Interactions
Mechanism of Actions
 Calcitonin inhibits osteoclastic bone resorption and reduces bone turnover. It decreases tubular reabsorption and promotes renal excretion of calcium, phosphate, sodium, magnesium and potassium.
Absorption: Rapidly inactivated (oral); peak plasma concentrations after 30-40 min (nasal), 15-25 min (IM).
Distribution: Protein binding: 30-40%.
Metabolism: Rapidly in the kidneys; blood and peripheral tissues.
Excretion: Urine (inactive metabolites, small amounts of unchanged drug); 70-90 min (elimination half-life).
Storage Conditions
 Intravenous: Refrigerate at 2-8°C. Nasal: Refrigerate at 2-8°C. Parenteral: Refrigerate at 2-8°C.
Storage
 Intravenous: Refrigerate at 2-8°C. Nasal: Refrigerate at 2-8°C. Parenteral: Refrigerate at 2-8°C.
Available As
  • Calcitonin 100 iu
  • Calcitonin 200 iu
  • Calcitonin 2200 iu
  • Calcitonin 50 iu

    • Subscribe for latest updates

    Subscribe to our e-mail newsletter to receive updates.

    No comments yet.

    Post Review about Calcitonin


    Calcitonin Containing Brands

    We are Developing Our database, More results coming soon.

    Calcitonin is used in following diseases

    We are Developing Our database, More results coming soon.

    Drug - Drug Interactions of Calcitonin

    We are Developing Our database, More results coming soon.