Buclizine

Indications
 Oral
Prophylaxis of motion sickness
Adult: As hydrochloride: 25 or 50 mg given 30 min before travelling, repeated after 4-6 hr, if necessary.
Oral
Migraine
Adult: As hydrochloride: 12.5 mg taken as soon as symptoms arise.
Child: 10-14 yr: 6.25 mg at the start of the symptoms. >14 yr: follow adult dose.
Oral
Nausea and vomiting
Adult: As hydrochloride: 25 or 50 mg tid.
Oral
Pruritic skin disorders
Adult: As hydrochloride: 25-50 mg daily.
Contraindications
 Hypersensitivity; neonates.
Warnings / Precautions
 Driving or operating machinery; open-angle glaucoma; urinary retention; prostatic hyperplasia, pyloroduodenal obstruction, epilepsy; renal and hepatic impairment; pregnancy.
Adverse Reactions
 Drowsiness, dizziness, incoordination; blurred vision; urinary retention; vomiting; rash; dry mouth; headache, nausea, epigastric pain, wt gain and diarrhoea.
Drug Interactions
 Potentially Fatal: Effect of alcohol, sedatives and other CNS depressants potentiated.
See Below for More buclizine Drug Interactions
Mechanism of Actions
 Buclizine is a piperazine antihistamine with antimuscarinic and moderate sedative properties. It is used mainly for its antiemetic action and in the treatment of migraine in combination with analgesics.
Administration
 Should be taken with food. (Take w/in ½ hr before meals.)
ATC Classification
 R06AE01 - buclizine ; Belongs to the class of piperazine derivatives used as systemic antihistamines.
Available As
  • Buclizine 25 mg
  • Buclizine 6 mg

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