Bromocriptine

Indications
Oral
Parkinson's disease
Adult: As adjunct to levodopa: 1st wk: Initially, 1-1.25 mg at night; 2nd wk: 2-2.5 mg at night; 3rd wk: 2.5 mg bid; 4th wk: 2.5 mg tid, then increased by 2.5 mg every 3-14 days as required. Maintenance: 10-40 mg daily.
Oral
Hypogonadism
Adult: 1-1.25 mg at bedtime increased to 2-2.5 mg at bedtime after 2-3 days and subsequently increased by 1 mg at 2-3 days intervals, up to 2.5 mg bid or more if necessary. Max: 30 mg daily.
Oral
Galactorrhoea
Adult: 1-1.25 mg at bedtime increased to 2-2.5 mg at bedtime after 2-3 days and subsequently increased by 1 mg at 2-3 days intervals, up to 2.5 mg bid or more if necessary. Max: 30 mg daily.
Oral
Infertility
Adult: 1-1.25 mg at bedtime increased to 2-2.5 mg at bedtime after 2-3 days and subsequently increased by 1 mg at 2-3 days intervals, up to 2.5 mg bid or more if necessary. Max: 30 mg daily.
Oral
Adjunct to surgery and radiotherapy in patients with acromegaly
Adult: Initially, 2.5 mg bid, may increase further by 2.5 mg every 2-3 days, if necessary up to 5 mg every 6 hr depending on response.
Oral
Suppression of lactation
Adult: 2.5 mg daily for 2-3 days, increased gradually to 2.5 mg bid for 14 days.
Oral
Prophylaxis of puerperal lactation
Adult: 2.5 mg on the day of delivery followed by 2.5 mg bid for 14 days.
Oral
Cyclical benign breast and menstrual disorders
Adult: 2.5 mg bid.
Contraindications
Breast carcinoma, hypersensitivity to ergot alkaloids, uncontrolled hypertension, severe ischaemic heart disease. Pregnancy and lactation.
Warnings / Precautions
Increased risk of conception, patients with peptic ulcer, diabetes, diabetic retinopathy, impaired hepatic or renal function, pleuropulmonary signs and symptoms, history of psychosis, CV disease, dementia or concurrent antihypertensive therapy, ability to drive vehicles or operating machinery may be impaired.
Adverse Reactions
Nausea, vomiting, gastric haemorrhage (acromegaly), dizziness, headache, drowsiness, depression, postural hypotension, nasal congestion, pleural effusion, mania, ataxia. High doses produce confusion, hallucinations, delirium, psychosis.
Drug Interactions
Bioavailability increased if given along with erythromycin. Alcohol reduces tolerance to bromocriptine and vice-versa. Effects of antihypertensives may be potentiated. Avoid concurrent psychotropics.
See Below for More bromocriptine Drug Interactions
Food Interactions
Food reduces nausea caused by bromocriptine.
Mechanism of Actions
Bromocriptine is a dopamine D2 and D3-agonist which works by activating postsynaptic dopamine receptors in the tuberoinfundibular and nigrostriatal pathways. It also inhibits the secretion of prolactin from the anterior pituitary and is used in the treatment of prolactinoma and in endocrinological disorders.
Absorption: 30% absorbed from the GIT (oral).
Distribution: Protein-binding: 90-96%
Metabolism: Extensive hepatic first-pass metabolism by hydrolysis to lysergic acid and peptides.
Excretion: Mainly via faeces, via urine (minimal amounts).
Administration
Should be taken with food.
ATC Classification
G02CB01 - bromocriptine ; Belongs to the class of prolactine inhibitors. Used to suppress lactation.
N04BC01 - bromocriptine ; Belongs to the class of dopamine agonist. Used in the management of Parkinson's disease.
Available As
  • Bromocriptine Mesylate 1.25 mg
  • Bromocriptine 1.25 mg
  • Bromocriptine Mesylate 2.5 mg
  • Bromocriptine 2.5 mg
  • Bromocriptine Mesylate 5 mg
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