Indications |
Oral Parkinson's disease Adult: As adjunct to levodopa: 1st wk: Initially, 1-1.25 mg at night; 2nd wk: 2-2.5 mg at night; 3rd wk: 2.5 mg bid; 4th wk: 2.5 mg tid, then increased by 2.5 mg every 3-14 days as required. Maintenance: 10-40 mg daily. Oral Hypogonadism Adult: 1-1.25 mg at bedtime increased to 2-2.5 mg at bedtime after 2-3 days and subsequently increased by 1 mg at 2-3 days intervals, up to 2.5 mg bid or more if necessary. Max: 30 mg daily. Oral Galactorrhoea Adult: 1-1.25 mg at bedtime increased to 2-2.5 mg at bedtime after 2-3 days and subsequently increased by 1 mg at 2-3 days intervals, up to 2.5 mg bid or more if necessary. Max: 30 mg daily. Oral Infertility Adult: 1-1.25 mg at bedtime increased to 2-2.5 mg at bedtime after 2-3 days and subsequently increased by 1 mg at 2-3 days intervals, up to 2.5 mg bid or more if necessary. Max: 30 mg daily. Oral Adjunct to surgery and radiotherapy in patients with acromegaly Adult: Initially, 2.5 mg bid, may increase further by 2.5 mg every 2-3 days, if necessary up to 5 mg every 6 hr depending on response. Oral Suppression of lactation Adult: 2.5 mg daily for 2-3 days, increased gradually to 2.5 mg bid for 14 days. Oral Prophylaxis of puerperal lactation Adult: 2.5 mg on the day of delivery followed by 2.5 mg bid for 14 days. Oral Cyclical benign breast and menstrual disorders Adult: 2.5 mg bid. |
Contraindications |
Breast carcinoma, hypersensitivity to ergot alkaloids, uncontrolled hypertension, severe ischaemic heart disease. Pregnancy and lactation. |
Warnings / Precautions |
Increased risk of conception, patients with peptic ulcer, diabetes, diabetic retinopathy, impaired hepatic or renal function, pleuropulmonary signs and symptoms, history of psychosis, CV disease, dementia or concurrent antihypertensive therapy, ability to drive vehicles or operating machinery may be impaired. |
Adverse Reactions |
Nausea, vomiting, gastric haemorrhage (acromegaly), dizziness, headache, drowsiness, depression, postural hypotension, nasal congestion, pleural effusion, mania, ataxia. High doses produce confusion, hallucinations, delirium, psychosis. |
Drug Interactions |
Bioavailability increased if given along with erythromycin. Alcohol reduces tolerance to bromocriptine and vice-versa. Effects of antihypertensives may be potentiated. Avoid concurrent psychotropics. See Below for More bromocriptine Drug Interactions |
Food Interactions |
Food reduces nausea caused by bromocriptine. |
Mechanism of Actions |
Bromocriptine is a dopamine D2 and D3-agonist which works by activating postsynaptic dopamine receptors in the tuberoinfundibular and nigrostriatal pathways. It also inhibits the secretion of prolactin from the anterior pituitary and is used in the treatment of prolactinoma and in endocrinological disorders. Absorption: 30% absorbed from the GIT (oral). Distribution: Protein-binding: 90-96% Metabolism: Extensive hepatic first-pass metabolism by hydrolysis to lysergic acid and peptides. Excretion: Mainly via faeces, via urine (minimal amounts). |
Administration |
Should be taken with food. |
ATC Classification |
G02CB01 - bromocriptine ; Belongs to the class of prolactine inhibitors. Used to suppress lactation. N04BC01 - bromocriptine ; Belongs to the class of dopamine agonist. Used in the management of Parkinson's disease. |
Available As |
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Bromocriptine
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Bromocriptine Containing Brands
Bromocriptine is used in following diseases
Drug - Drug Interactions of Bromocriptine
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