Indications |
Oral Benign gastric and duodenal ulceration Adult: 240 mg bid or 120 mg 4 times daily for 4 wk, may be extended to 8 wk if needed. May also be repeated after one mth of drug-free interval. Renal impairment: Moderate-severe impairment: Avoid use. Oral H.pylori infection Adult: 120 mg 4 times daily in combination with other drugs given for 2 wk. Renal impairment: Moderate-severe impairment: Avoid use. |
Contraindications |
Moderate-severe renal insufficiency. Pregnancy, child <14 yr. |
Warnings / Precautions |
Lactation. Monitor renal function regularly. |
Adverse Reactions |
Darkening of tongue or stools. Nausea, vomiting, bone and joint toxicity. Potentially Fatal: Possibility of bismuth poisoning and fatal encephalopathy in patients with renal impairment or if given over prolonged periods. Renal failure and liver damage. |
Overdose Reactions |
Overdosage may lead to serious adverse effects such as renal failure, encephalopathy and neurotoxicity. May consider gastric lavage, purgation and hydration. Chelating agents may be useful. |
Drug Interactions |
Food, milk, antacids, tetracyclines and H2-receptor antagonists reduce activity of drug. See Below for More bismuth subcitrate Drug Interactions |
Mechanism of Actions |
Bismuth subcitrate is used in the management of gastric and duodenal ulcers and specifically against H.pylori as part of a triple drug regimen. It exerts bactericidal action against H.pylori which is accepted to be the causative factor in chronic gastritis and duodenal ulcer. Absorption: Slightly absorbed (oral); increased absorption with increased gastric pH. Distribution: Throughout body tissues, bones (absorbed bismuth). Metabolism: Poorly soluble bismuth compounds are mostly converted to insoluble bismuth oxide, hydroxide and oxychloride in acidic pH of the stomach. Excretion: Faeces (unabsorbed bismuth); urine (absorbed bismuth); 5 days (plasma half-life). |
Storage Conditions |
Oral: Store below 25°C. |
ATC Classification |
A02BX05 - bismuth subcitrate ; Belongs to the class of other drugs used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD). |
Storage |
Oral: Store below 25°C. |
Available As |
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Bismuth Subcitrate
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Bismuth Subcitrate Containing Brands
Bismuth Subcitrate is used in following diseases
Drug - Drug Interactions of Bismuth Subcitrate
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