Bisacodyl

Indications
 Oral
Constipation
Adult: 5-10 mg at night.
Child: >4 yr: 5 mg at night time.
Elderly:
Oral
Bowel evacuation
Adult: Initially, 10-20 mg the night before the procedure followed by 10 mg suppository admin rectally the next morning.
Child: >10 yr: Same as adult dose. 4-10 yr: 5 mg the night before the procedure and 5 mg suppository admin rectally the following morning. .
Rectal
Constipation
Adult: 10 mg suppository/enema admin in the morning.
Child: <10 yr: 5 mg in the morning.
Contraindications
 Acute surgical abdomen or intestinal obstruction, severe dehydration, faecal impaction, chronic use.
Warnings / Precautions
 Swallow the tab whole. Pregnancy; inflammatory bowel disease.
Adverse Reactions
 Abdominal discomfort (colic, cramps). Suppositories may cause irritation and proctitis.
Overdose Reactions
 Overdosage may result in diarrhoea with excessive loss of water and electrolytes.
Drug Interactions
 Do not give antacids or milk within 1 hr of taking the drug (enteric coated).
See Below for More bisacodyl Drug Interactions
Lab Interactions
 False urinary glucose levels.
Mechanism of Actions
 Bisacodyl acts mainly in the large intestine by increasng its motility to effect bowel evacuation.
Onset: 6-12 hr (oral). 15-60 min (rectal).
Absorption: Minimal from the GI tract (oral, as enteric-coated tablets/suppositories).
Metabolism: Converted to bis(p-hydroxyphenyl)pyridyl-2-methane by intestinal or bacterial enzymes.
Excretion: Faeces; urine (as glucuronide).
Administration
 Should be taken on an empty stomach. (Take on an empty stomach for rapid effect. Do not take w/in 1 hr of antacids, milk or other dairy products.)
Storage Conditions
 Oral: Store below 25°C. Rectal: Store below 25°C.
ATC Classification
 A06AB02 - bisacodyl ; Belongs to the class of contact laxatives.
A06AG02 - bisacodyl ; Belongs to the class of enemas. Used in the treatment of constipation.
Storage
 Oral: Store below 25°C. Rectal: Store below 25°C.
Available As
  • Bisacodyl 10 mg
  • Bisacodyl 5 mg

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