Bezafibrate

Indications
 Oral
Hyperlipidaemias
Adult: 200 mg tid, may increase dose gradually over 5-7 days. Maintenance: 200 mg bid. As modified-release preparation: 400 mg daily.
Renal impairment: Contraindicated in dialysis patients.
CrCl (ml/min)Dosage Recommendation
40-60400 mg daily
15-40200 mg daily or on alternate days
<15Contraindicated
Contraindications
 Advanced liver disease, primary biliary cirrhosis; gallstones or gallbladder disorders; severe renal insufficiency, hypoalbuminaemia. Pregnancy, lactation.
Warnings / Precautions
 Renal impairment; children. In patients receiving cholestyramine, the 2 drugs must be separated by 2 hr. History of jaundice or hepatic disorder; renal impairment (reduce dose); hypoalbuminaemia or nephrotic syndrome.
Adverse Reactions
 GI upset; pruritus, urticaria, alopoecia, impotence; vertigo, fatigue; increased serum transaminases.
Potentially Fatal: Leucopenia, thrombocytopenia; myotoxicity.
Drug Interactions
 Cholestyramine inhibits bezafibrate absorption.
Potentially Fatal: Enhanced effects of oral anticoagulants.
See Below for More bezafibrate Drug Interactions
Mechanism of Actions
 Bezafibrate causes significant reduction in plasma by reducing the conc of very low-density lipoproteins (VLDL). It also increases the activity of lipoprotein lipase and several other enzymes.
Absorption: Readily absorbed from the GI tract (oral).
Distribution: Protein-binding: 95%.
Excretion: Urine (50% unchanged drug and metabolites); faeces (small amounts); 2 hr (elimination half-life).
Administration
 Should be taken with food.
Storage Conditions
 Oral: Store below 25°C.
ATC Classification
 C10AB02 - bezafibrate ; Belongs to the class of fibrates. Used in the treatment of hyperlipidemia.
Storage
 Oral: Store below 25°C.
Available As
  • Bezafibrate 200 mg
  • Bezafibrate 400 mg

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