Bethanechol Chloride

Urinary retention
Adult: 10-50 mg 3-4 times daily.

Special Populations: Doses should be adjusted according to patient requirements.
Hypersensitivity, hyperthyroidism, peptic ulcer, obstructive pulmonary disease, pronounced bradycardia or hypotension, vasomotor instability, epilepsy, parkinsonism, mechanical obstruction of the GIT, bladder neck obstruction, spastic GI disturbances; IV/IM admin; lactation.
Warnings / Precautions
Urinary retention, pregnancy, children.
Adverse Reactions
Nausea, vomiting, abdominal cramps, diarrhoea; frequency of micturition; blurred vision; tachycardia, flushing; headache, malaise.
Overdose Reactions
Signs include abdominal discomfort, salivation, skin flushing, sweating, nausea and vomiting. Antidote: Atropine Sulfate. Recommended dose for adults is 0.6 mg. Doses can be given repeated every 2 hr, according to clinical response. Recommended dosage in infants and children up to 12 yr: 0.01 mg/kg (max: 0.4 mg/dose) repeated every 2 hr as needed until the desired effect is achieved. SC inj is preferred except in emergencies when the IV route may be used.
Drug Interactions
Potentially Fatal: Additive effects with cholinergic agents leading to toxicity; critical fall in BP with ganglionic blockers.
See Below for More bethanechol chloride Drug Interactions
Lab Interactions
Interferes with liver function tests.
Mechanism of Actions
Bethanecol has a stimulant action on the muscarinic cholinergic receptors in the smooth muscles of the bladder and GI tract, leading to increased ureteric and oesophagal peristalsis, increased pancreatic and GI secretions as well as bladder muscle contraction.
Onset: 30-90 min (oral); 5-15 min (SC).
Duration: 1-2 hr.
Absorption: Poor absorption from the GI tract (oral).
Distribution: Does not cross the blood-brain barrier.
Metabolism: Not hydrolysed by cholinesterases.
Should be taken on an empty stomach (i.e. At least one hour before food or two hours after food). (Take on an empty stomach 1 hr before or 2 hr after meals.)
Storage Conditions
Oral: Store at 20-25°C.
ATC Classification
N07AB02 - bethanechol ; Belongs to the class of choline esters. Used as parasympathomimetics.
Oral: Store at 20-25°C.
Available As
  • Bethanechol Chloride 25 mg
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