Bethanechol Chloride

Indications
 Oral
Urinary retention
Adult: 10-50 mg 3-4 times daily.

Special Populations: Doses should be adjusted according to patient requirements.
Contraindications
 Hypersensitivity, hyperthyroidism, peptic ulcer, obstructive pulmonary disease, pronounced bradycardia or hypotension, vasomotor instability, epilepsy, parkinsonism, mechanical obstruction of the GIT, bladder neck obstruction, spastic GI disturbances; IV/IM admin; lactation.
Warnings / Precautions
 Urinary retention, pregnancy, children.
Adverse Reactions
 Nausea, vomiting, abdominal cramps, diarrhoea; frequency of micturition; blurred vision; tachycardia, flushing; headache, malaise.
Overdose Reactions
 Signs include abdominal discomfort, salivation, skin flushing, sweating, nausea and vomiting. Antidote: Atropine Sulfate. Recommended dose for adults is 0.6 mg. Doses can be given repeated every 2 hr, according to clinical response. Recommended dosage in infants and children up to 12 yr: 0.01 mg/kg (max: 0.4 mg/dose) repeated every 2 hr as needed until the desired effect is achieved. SC inj is preferred except in emergencies when the IV route may be used.
Drug Interactions
 Potentially Fatal: Additive effects with cholinergic agents leading to toxicity; critical fall in BP with ganglionic blockers.
See Below for More bethanechol chloride Drug Interactions
Lab Interactions
 Interferes with liver function tests.
Mechanism of Actions
 Bethanecol has a stimulant action on the muscarinic cholinergic receptors in the smooth muscles of the bladder and GI tract, leading to increased ureteric and oesophagal peristalsis, increased pancreatic and GI secretions as well as bladder muscle contraction.
Onset: 30-90 min (oral); 5-15 min (SC).
Duration: 1-2 hr.
Absorption: Poor absorption from the GI tract (oral).
Distribution: Does not cross the blood-brain barrier.
Metabolism: Not hydrolysed by cholinesterases.
Administration
 Should be taken on an empty stomach (i.e. At least one hour before food or two hours after food). (Take on an empty stomach 1 hr before or 2 hr after meals.)
Storage Conditions
 Oral: Store at 20-25°C.
ATC Classification
 N07AB02 - bethanechol ; Belongs to the class of choline esters. Used as parasympathomimetics.
Storage
 Oral: Store at 20-25°C.
Available As
  • Bethanechol Chloride 25 mg

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