Parkinson's disease
Adult: Usually given with L-dopa in the ratio of 1 part of benserazide base to 4 parts of L-dopa. As capsule containing levodopa 100 mg and benserazide 25 mg: Initially, 1 capsule 1-2 times/day; increase every 3-4 days until therapeutic effect; optimal dosage: 4-8 capsules/day, given in 4-6 divided doses. Max (per day): Levodopa 1200 mg/ benserazide 300 mg.
Avoid in patients <25 yr, pregnancy or women of child-bearing potential in the absence of adequate contraception.
Mechanism of Actions
It is a peripheral dopa-decarboxylase inhibitor with little or no pharmacological activity when used alone. It inhibits peripheral decarboxylation of L-dopa to dopamine, thus effective brain concentrations of dopamine are produced with lower doses of L-dopa. It is used as an adjunct to levodopa in the treatment of parkinsonism.
Absorption: Rapidly absorbed (approx 58%). Concurrent admin with L-dopa increases the absorption slightly.
Metabolism: Mainly metabolised in the gut.
Excretion: Rapidly excreted as metabolites in the urine mostly within the 1st 6 hr; 85% excretion within 12 hr.
Storage Conditions
Oral: Store at 15-30°C.
Oral: Store at 15-30°C.
Available As
  • Benserazide 25 mg
  • Benserazide 28.5 mg
  • Benserazide 50 mg
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