Bacampicillin

Indications
 Oral
Biliary tract infections
Adult: 400-800 mg bid-tid.
Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.
Oral
Endocarditis
Adult: 400-800 mg bid-tid.
Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.
Oral
Meningitis
Adult: 400-800 mg bid-tid.
Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.
Oral
Otitis media
Adult: 400-800 mg bid-tid.
Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.
Oral
Peritonitis
Adult: 400-800 mg bid-tid.
Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.
Oral
Pneumonia
Adult: 400-800 mg bid-tid.
Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.
Oral
Septicaemia
Adult: 400-800 mg bid-tid.
Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.
Oral
Bronchitis
Adult: 400-800 mg bid-tid.
Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.
Oral
Perinatal streptococcal infections
Adult: 400-800 mg bid-tid.
Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.
Oral
Typhoid and paratyphoid fever
Adult: 400-800 mg bid-tid.
Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.
Oral
Gastroenteritis
Adult: 400-800 mg bid-tid.
Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.
Oral
Listeriosis
Adult: 400-800 mg bid-tid.
Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.
Oral
Urinary tract infections
Adult: 400-800 mg bid-tid.
Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.
Oral
Uncomplicated gonorrhoea
Adult: 1.6 g with 1 g probenecid as a single dose.
Contraindications
 Infectious mononucleosis, lymphatic leukemia, HIV infection; hypersensitivity to penicillins.
Warnings / Precautions
 Very high doses in poor renal function (risk of neurotoxicity) or heart failure. Avoid contact, skin sensitisation may occur. Monitor serum potassium concentration, renal and haematological status. Spirochete infections particularly syphilis; suprainfection with penicillin-resistant organisms with prolonged use; avoid intrathecal route. Discontinue in case of skin rash.
Adverse Reactions
 Hypersensitivity reactions including uticaria; fever; joint pains; rashes; angioedema; serum sickness-like reactions; haemolytic anaemia; interstitial nephritis; neutropenia; thrombocytopenia; CNS toxicity including convulsions; diarrhoea; antibiotic-associated colitis. Nausea; vomiting; pseudomembranous colitis.
Drug Interactions
 Probenecid prolongs T1/2 of bacampicillin. Bacteriostatic drugs e.g. chloramphenicol, tetracyclines; other antibacterials; anticoagulants.
See Below for More bacampicillin Drug Interactions
Lab Interactions
 May interfere with diagnostic tests for urinary glucose using copper sulfate, direct Coomb's test, and test for urinary or serum proteins. May interfere with diagnostic tests that use bacteria.
Mechanism of Actions
 Bacampicillin has the antimicrobial action of ampicillin in vivo. It needs to be hydrolysed to ampicillin since it possesses no intrinsic activity.
Absorption: Rapidly and absorbed in the GI tract.
Metabolism: Hydrolysed in intestinal walls and plasma to ampicillin.
Excretion: About 75% of a dose is excreted in the urine within 8 hr as ampicillin.
Administration
 May be taken with or without food. (May be taken w/ meals to reduce GI discomfort.)
ATC Classification
 J01CA06 - bacampicillin ; Belongs to the class of penicillins with extended spectrum. Used in the systemic treatment of infections.
Available As
  • Bacampicillin 200 mg
  • Bacampicillin 400 mg

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