Azelastine

Indications
 Nasal
Rhinitis
Adult: 140 mcg by nasal spray into each nostril bid.
Child: ≥5 yr: 140 mcg by nasal spray into each nostril bid.
Ophthalmic
Conjunctivitis
Adult: Instill 1-2 drops of 0.05% solution into the affected eye/s bid, may increase to four times daily in severe cases.
Child: ≥4 yr: Instill 1-2 drops of 0.05% solution into the affected eye/s bid, may increase to four times daily in severe cases.
Contraindications
 Hypersensitivity.
Warnings / Precautions
 Pregnancy, lactation. Tip of the bottle should be dipped in boiling water, dried and capped appropriately after every use.
Adverse Reactions
 Irritation, stinging and itching of the nasal mucosa. Sneezing, nosebleeds, headache; nausea, taste disturbances, somnolence, dry mouth.
Overdose Reactions
 Accidental oral ingestion of large doses may lead to tremor, convulsions, decreased muscle tone and salivation. General supportive measures should be used.
Drug Interactions
 Additive effects with CNS depressants and ethanol.
See Below for More azelastine Drug Interactions
Mechanism of Actions
 Azelastine blocks histamine H1-receptor activity and inhibits release of inflammatory mediators from mast cells.
Absorption: 40% absorbed sytemically through the nasal mucosa (intranasal).
Metabolism: Hepatic.
Excretion: Via faeces.
Storage Conditions
 Nasal: Store at 20-25°C. Ophthalmic: Store at 2-25°C.
ATC Classification
 R01AC03 - azelastine ; Belongs to the class of topical antiallergic preparations, excluding corticosteroids. Used as antiallergic agents.
R06AX19 - azelastine ; Belongs to the class of other antihistamines for systemic use.
S01GX07 - azelastine ; Belongs to the class of other ophthalmologic antiallergics.
Storage
 Nasal: Store at 20-25°C. Ophthalmic: Store at 2-25°C.
Available As
  • Azelastine 0.05% w/v
  • Azelastine 0.1% w/v
  • Azelastine 0.10% w/v
  • Azelastine 0.5 mg
  • Azelastine 140 mcg

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