Azelaic Acid

Indications
 Topical/Cutaneous
Acne
Adult: ≥12 yr: As a 20% cream or 15% gel: Apply and massage gently into the affected areas bid. Skin should be cleansed and patted dry before application. Improvement may be visible within 4 wk. Treatment generally should not exceed 6 mth although extended duration may be needed in some patients.
Topical/Cutaneous
Rosacea
Adult: As a 15% gel: Apply and massage gently into the affected areas bid. Skin should be cleansed and patted dry before application.
Warnings / Precautions
 Pregnancy, lactation. Avoid contact with eyes, mouth or other mucous membranes. Occlusive dressings or wrappings should not be used. Recommend patient to use only very mild soaps or soapless cleansing lotions for facial washing. Monitor for hypopigmentation in patients with dark complexion. Safety and efficacy not established in children <12 yr.
Adverse Reactions
 Local skin irritation (e.g. erythema, scaling, itching or burning). Hypopigmentation and rarely, photosensitivity reactions.
Mechanism of Actions
 Azelaic acid is a naturally-occurring aliphatic dicarboxylic acid. The exact mechanism of action in treatment of acne vulgaries has not been fully established. It is believed to inhibit the growth of susceptible organisms (mainly Propionibacteria Acnes) on the skin surface, and inhibits follicular keratinisation thus restricts the development of comedones. Mechanism of action in the treatment of rosacea is unknown.
Absorption: Low percutaneous absorption. Penetrates all layers of skin after topical application with more rapid penetration into damaged skin than intact skin.
Distribution: Protein binding: About 43%.
Excretion: Azelaic acid absorbed through the skin is excreted in urine (as unchanged drug and short-chained dicarboxylic acids metabolites).
Storage Conditions
 Topical/Cutaneous: Store at 15-30°C.
ATC Classification
 D10AX03 - azelaic acid ; Belongs to the class of other topical preparations used in the treatment of acne.
Storage
 Topical/Cutaneous: Store at 15-30°C.
Available As
  • Azelaic Acid 10%
  • Azelaic Acid 20%

    • Subscribe for latest updates

    Subscribe to our e-mail newsletter to receive updates.

    No comments yet.

    Post Review about Azelaic Acid


    Azelaic Acid Containing Brands

    We are Developing Our database, More results coming soon.

    Azelaic Acid is used in following diseases

    We are Developing Our database, More results coming soon.

    Drug - Drug Interactions of Azelaic Acid

    We are Developing Our database, More results coming soon.