Indications |
Oral Advanced or locally advanced breast cancer, Adjuvant treatment in early breast cancer Adult: In postmenopausal women: 1 mg daily. Adjuvant treatment may be continued for up to 5 yr. |
Contraindications |
Pregnancy. Hypersensitivity, premenopausal women. |
Warnings / Precautions |
Lactation. Moderate or severe hepatic impairment, hyperlipidaemias. Laboratory test for menopause if status is doubtful. Bone mass density test should be conducted at the start of the therapy and at regular intervals thereafter. |
Adverse Reactions |
Hot flushes, vaginal dryness, vaginal bleeding, hair thinning, anorexia, nausea, vomiting, diarrhoea, headache, arthralgia, bone fractures, rash, oedema, myalgia, fever, weight gain, leucopenia, flu-like syndrome, asthenia, dizziness, drowsiness, abnormal liver enzyme values, thrombophloebitis, anaphylaxis. |
Overdose Reactions |
General supportive care, frequent monitoring of vital signs and close observation of the patient are recommended. Vomiting may be induced if patient is alert. |
Drug Interactions |
Efficacy decreased by oestrogens. Plasma concentrations decreased by tamoxifen. See Below for More anastrozole Drug Interactions |
Mechanism of Actions |
Anastrozole prevents conversion of androstenedione to estrone and testosterone to oestradiol by inhibiting aromatase, thus leading to significantly reduced serum oestradiol concentrations. Absorption: Rapidly and almost completely absorbed from the GI tract (oral); peak plasma concentrations after 2 hr. May decrease the rate of absorption with food. Distribution: Protein-binding: 40%. Metabolism: Hepatic. Excretion: Via urine (as metabolites); 50 hr (elimination half-life). |
Administration |
May be taken with or without food. |
Storage Conditions |
Oral: Store at 20-25°C. |
ATC Classification |
L02BG03 - anastrozole ; Belongs to the class of enzyme inhibitors. Used in endocrine therapy. |
Storage |
Oral: Store at 20-25°C. |
Available As |
|
Anastrozole
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Anastrozole Containing Brands
Anastrozole is used in following diseases
Drug - Drug Interactions of Anastrozole
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