Amrinone

Indications
 Intravenous
Heart failure
Adult: Loading dose: 750 mcg/kg by slow inj over 2-3 min (may be repeated after 30 minutes if necessary). Maintenance: 5-10 mcg/kg/min by infusion. Max cumulative dose: 10 mg/kg in 24 hr.

Incompatibility: Incompatible with glucose-containing solutions and furosemide.
Contraindications
 Hypersensitivity.
Warnings / Precautions
 Obstructive pulmonary or aortic disease, hypertrophic cardiomyopathy; BP and heart rate monitored during drug administration; fluid and electrolyte balance should be maintained; platelet counts and liver function should be monitored; protect amp from light. Pregnancy and lactation.
Adverse Reactions
 GI disturbances, nausea, vomiting, thrombocytopaenia, hypotension, chest pain, hypersensitivity, myositis, vasculitis, nail discoloration, Inj site pain, decreased tear production.
Potentially Fatal: Cardiac arrhythmia, hepatotoxicity.
Overdose Reactions
 May result in severe hypotension. General supportive and symptomatic treatment, including circulatory support, should also be initiated as necessary.
Drug Interactions
 Chemical interaction with precipitation occurs with amrinone and dextrose or furosemide. Thus drug mixing should be avoided.
Potentially Fatal: Concurrent usage with disopyramide may lead to severe hypotension.
See Below for More amrinone Drug Interactions
Mechanism of Actions
 Amrinone is a phosphodiesterase inhibitor which has vasodilating and positive inotropic properties. It causes an increase in cyclic adenosine monophosphate conc leading to greater contractile force in cardiac muscle.
Distribution: 10-22% bound to plasma proteins. Half-life after IV admin: 4-6 hr.
Metabolism: Partially metabolised in liver.
Excretion: 40% excreted unchanged.
Storage Conditions
 Intravenous: Store at 15-30°C.
ATC Classification
 C01CE01 - amrinone ; Belongs to the class of phosphodiesterase inhibitors. Used in the treatment of heart failure.
Storage
 Intravenous: Store at 15-30°C.
Available As
  • Amrinone 100 mg
  • Amrinone 5 mg
  • Amrinone 50 mg

    • Subscribe for latest updates

    Subscribe to our e-mail newsletter to receive updates.

    No comments yet.

    Post Review about Amrinone


    Amrinone Containing Brands

    We are Developing Our database, More results coming soon.

    Amrinone is used in following diseases

    We are Developing Our database, More results coming soon.

    Drug - Drug Interactions of Amrinone

    We are Developing Our database, More results coming soon.