Indications |
Oral Osteopetrosis Adult: 10 mg daily or 70 mg once wkly.
Oral Paget's disease of bone Adult: 40 mg daily for 6 mth; may be repeated if necessary after 6-mth post-treatment evaluation period. Oral Prophylaxis of postmenopausal osteoporosis Adult: 5 mg once daily or 35 mg once wkly.
Oral Corticosteroid-induced osteoporosis Adult: Treatment and prevention: 5 mg daily; may increase to 10 mg daily in women who do not receive HRT. Special Populations: Do not take this medication with mineral water, coffee, tea or juice, and at bedtime or before rising. Stand or sit upright for at least 30 min and do not lie down until after breakfast. |
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Contraindications |
Hypocalcaemia; oesophageal abnormalities and factors which delay oesophageal emptying; severe renal impairment; hypersensitivity; inability to stand or sit upright for ≥30 min. Pregnancy, lactation. | ||||||||
Warnings / Precautions |
Upper GI disorders (discontinue if symptoms worsen); history of ulcers, active GI bleeding. Correct vitamin D and calcium deficiency before starting therapy. To be taken half an hr before breakfast and remain upright for at least 30 minutes after admin. Not recommended for use in patients with CrCl <35 ml/min. | ||||||||
Adverse Reactions |
Oesophagitis, oesophageal ulcers and erosions, dysphagia, heartburn, retrosternal pain, abdominal pain, distension, diarrhoea, constipation, flatulence, headache, rash, erythema, musculoskeletal pain, transient decreases in serum phosphate. | ||||||||
Overdose Reactions |
Symptoms may include hypocalcaemia, hypophosphataemia and upper GI adverse events, such as upset stomach, heartburn, esophagitis, gastritis or ulcer. Milk or antacids should be given to bind alendronate. Should not induce vomiting due to the risk of oesophageal irritation. Patient should remain fully upright. Dialysis would not be beneficial. | ||||||||
Drug Interactions |
Concomitant iron, calcium supplements and antacids hinder alendronate absorption. Concomitant aspirin or NSAIDs may increase the incidence of adverse GI effects. See Below for More alendronic acid Drug Interactions |
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Food Interactions |
Food, mineral water, coffee, tea and juice interfere with absorption of alendronate. | ||||||||
Mechanism of Actions |
Alendronic acid reduces bone resorption by inhibiting the action of osteoclasts. Absorption: Poorly absorbed from the GIT (oral); reduced by food. Distribution: Protein-binding: 78% Excretion: Urine (50%); remainder is sequestered to bone. |
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Administration |
Should be taken on an empty stomach. (Take w/ a full glass of plain water at least ½ hr before the 1st food/drink/medication of the day & remain in sitting/upright position for at least ½ hr. Swallow whole, do not chew/crush.) |
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ATC Classification |
M05BA04 - alendronic acid ; Belongs to the class of bisphosphonates. Used in the treatment of bone diseases. | ||||||||
Available As |
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Alendronic Acid
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Alendronic Acid Containing Brands
Alendronic Acid is used in following diseases
Drug - Drug Interactions of Alendronic Acid
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