Aclarubicin

Indications
 Intravenous
Malignant blood disorders
Adult: Initially: 175-300 mg/m2 given in divided doses over 3-7 consecutive days via IV infusion over 30-60 minutes. Maintenance: 25-100 mg/m2 in a single infusion every 3-4 wk.
Contraindications
 Pregnancy, lactation; CV disease.
Warnings / Precautions
 Myocardial irradiation and use of radiotherapy. Hepatic or renal impairment. Elderly.
Adverse Reactions
 Nausea, vomiting, mucositis, irritant to tissue, sore mouth, bone-marrow suppression, hyperuricaemia. Alopoecia (rare).
Potentially Fatal: Cardiotoxicity (rare), myelosuppression in patients who received mitomycin or a nitrosourea, leucopenia.
Drug Interactions
 Other cardiotoxic drugs e.g. daunorubicin or cyclophosphamide, live vaccines; decreases effects of digoxin, oral anticoagulants, phenytoin and suxamethonium.
See Below for More aclarubicin Drug Interactions
Lab Interactions
 Elevated bilirubin level.
Mechanism of Actions
 Aclarubicin is an anthracycline, a cytotoxic antibiotic, and inhibits RNA synthesis through intercalation.
Distribution: Rapidly distributed into tissues after IV admin.
Metabolism: Extensively metabolised.
Excretion: Triphasic clearance. Terminal elimination half-life: About 3 hr. Excreted in urine mainly as metabolites.
ATC Classification
 L01DB04 - aclarubicin ; Belongs to the class of cytotoxic antibiotics, anthracyclines and related substances. Used in the treatment of cancer.
Available As
  • Aclarubicin 20 mg

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