Tadalafil vs Alpha1-Blockers

Interacting Drugs
Tadalafil
vs
Alpha1-Blockers
Security Level
Moderate, Consider therapy modification
Mechanism
Alpha1-Blockers: Phosphodiesterase 5 Inhibitors may enhance the hypotensive effect of Alpha1-Blockers.
Management
Ensure patient is stable on alpha 1 blocker before starting PDE5 inhibitor; initiate PDE5 inhibitor at lowest possible dose. If patient stable on PDE5 inhibitor, initiate alpha 1 blocker at lowest dose.

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