Rivaroxaban vs CYP3A4 Inducers (Strong)

Interacting Drugs
Rivaroxaban
vs
CYP3A4 Inducers (Strong)
Security Level
Moderate, Consider therapy modification
Mechanism
CYP3A4 Inducers (Strong): May decrease the serum concentration of Rivaroxaban.
Management
Avoid concurrent use of rivaroxaban and strong CYP3A4 inducers when possible. If such a combination is used, the U.S. labeling recommends an increase in rivaroxaban dose; Canadian labeling does not make specific dose increase recommendations.

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