Quinidine vs Vardenafil

Interacting Drugs
Quinidine
vs
Vardenafil
Security Level
Moderate, Consider therapy modification
Mechanism
Vardenafil: CYP3A4 Inhibitors (Strong) may increase the serum concentration of Vardenafil.
Management
Limit the vardenafil dose to 2.5 mg/24-hour period when used with strong CYP3A4 inhibitors. With ritonavir limit dose to 2.5 mg/72-hour period. With lower doses of some inhibitors, a reduction to 5 mg/24-hour period may be adequate.

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