Quinidine vs Saxagliptin

Interacting Drugs
Quinidine
vs
Saxagliptin
Security Level
Moderate, Consider therapy modification
Mechanism
Saxagliptin: CYP3A4 Inhibitors (Strong) may increase the serum concentration of Saxagliptin.
Management
Limit saxagliptin adult dose to 2.5 mg/day and monitor for increased saxagliptin levels/effects (e.g., hypoglycemia) when used with a strong CYP3A4 inhibitor. Monitor for decreased saxagliptin levels/effects if discontinuing CYP3A4 inhibitor.

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