Quinidine vs Mefloquine

Interacting Drugs
Quinidine
vs
Mefloquine
Security Level
Major, Avoid combination
Mechanism
Mefloquine: QuiNIDine may enhance the adverse/toxic effect of Mefloquine. Specifically, the risk for QTc-prolongation and the risk for convulsions may be increased.
Management
Avoid concurrent use, and delay administration of mefloquine until at least 12 hours after the last dose of quinidine when possible.

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