Oxaprozin vs Drotrecogin Alfa

Interacting Drugs
Oxaprozin
vs
Drotrecogin Alfa
Security Level
Moderate, Consider therapy modification
Mechanism
Drotrecogin Alfa: Antiplatelet Agents may enhance the adverse/toxic effect of Drotrecogin Alfa. Bleeding may occur.
Management
When possible, avoid use of drotrecogin within 7 days of use of any IIb/IIIa antagonists, higher dose aspirin (more than 650 mg/day), or use of other antiplatelet agents.

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