Nitroglycerin (glyceryl trinitrate) vs Rosiglitazone

Interacting Drugs
Nitroglycerin (glyceryl trinitrate)
vs
Rosiglitazone
Security Level
Moderate, Consider therapy modification
Mechanism
Rosiglitazone: Vasodilators (Organic Nitrates) may enhance the adverse/toxic effect of Rosiglitazone. Specifically, a greater risk of myocardial ischemia was reported for users of this combination in a meta-analysis.
Management
Consider alternatives to this combination when possible. Rosiglitazone prescribing information states that the combination of rosiglitazone and a nitrate is not recommended.

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