Nadolol and bendroflumethiazide vs Dronedarone

Interacting Drugs
Nadolol and bendroflumethiazide
vs
Dronedarone
Security Level
Moderate, Consider therapy modification
Mechanism
Dronedarone: May enhance the bradycardic effect of Beta-Blockers. Dronedarone may increase the serum concentration of Beta-Blockers. This likely applies only to those agents that are metabolized by CYP2D6.
Management
Use lower initial beta-blocker doses; adequate tolerance of the combination, based on ECG findings, should be confirmed prior to any increase in beta-blocker dose.

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