Mitotane vs Spironolactone

Interacting Drugs
Mitotane
vs
Spironolactone
Security Level
Moderate, Consider therapy modification
Mechanism
Spironolactone: May diminish the therapeutic effect of Mitotane.
Management
Consideration should be given to discontinuing spironolactone prior to initiating mitotane in order to eliminate the risk of therapeutic failure of the mitotane.

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