Lansoprazole, amoxicillin, and clarithromycin vs P-glycoprotein/ABCB1 Substrates

Interacting Drugs
Lansoprazole, amoxicillin, and clarithromycin
vs
P-glycoprotein/ABCB1 Substrates
Security Level
Minor, Monitor Therapy
Mechanism
P-glycoprotein/ABCB1 Substrates: May increase the serum concentration of P-glycoprotein/ABCB1 Inhibitors. P-glycoprotein inhibitors may also enhance the distribution of p-glycoprotein substrates to specific cells/tissues/organs where p-glycoprotein is present in large amounts (e.g., brain, T-lymphocytes, testes, etc.).
Management
Monitor therapy

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