Ketorolac (systemic) vs PRALAtrexate

Interacting Drugs
Ketorolac (systemic)
vs
PRALAtrexate
Security Level
Minor, Monitor Therapy
Mechanism
PRALAtrexate: Nonsteroidal Anti-Inflammatory Agents may increase the serum concentration of PRALAtrexate. More specifically, NSAIDS may decrease the renal excretion of pralatrexate.
Management
Closely monitor for increased pralatrexate serum levels and/or toxicity if used concomitantly with an NSAID. Monitor for decreased pralatrexate serum levels with NSAID discontinuation.

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