Imipenem and cilastatin vs Valproic Acid

Interacting Drugs
Imipenem and cilastatin
vs
Valproic Acid
Security Level
Moderate, Consider therapy modification
Mechanism
Valproic Acid: Carbapenems may decrease the serum concentration of Valproic Acid.
Management
Concurrent use of carbapenem antibiotics with valproic acid is generally not recommended. Alternative antimicrobial agents should be considered, but if a concurrent carbapenem is necessary, consider additional anti-seizure medication.

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