Imipenem and cilastatin vs Typhoid Vaccine

Interacting Drugs
Imipenem and cilastatin
vs
Typhoid Vaccine
Security Level
Moderate, Consider therapy modification
Mechanism
Typhoid Vaccine: Antibiotics may diminish the therapeutic effect of Typhoid Vaccine. Only the live attenuated Ty21a strain is affected.
Management
Vaccination with live attenuated typhoid vaccine (Ty21a) should be avoided in patients being treated with systemic antibacterial agents. Use of this vaccine should be postponed until at least 24 hours after cessation of antibacterial agents.

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