Ezetimibe and simvastatin vs DAPTOmycin

Interacting Drugs
Ezetimibe and simvastatin
vs
DAPTOmycin
Security Level
Moderate, Consider therapy modification
Mechanism
DAPTOmycin: HMG-CoA Reductase Inhibitors may enhance the adverse/toxic effect of DAPTOmycin. Specifically, the risk of skeletal muscle toxicity may be increased.
Management
Consider temporarily stopping HMG-CoA reductase inhibitor therapy prior to daptomycin. If used together, regular (i.e., at least weekly) monitoring of CPK concentrations is recommended.

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