Etoposide vs CycloSPORINE (Systemic)

Interacting Drugs
Etoposide
vs
CycloSPORINE (Systemic)
Security Level
Moderate, Consider therapy modification
Mechanism
CycloSPORINE (Systemic): May decrease the metabolism of Etoposide.
Management
Consider reducing the dose of etoposide by 50% if the patient is receiving, or has recently received, cyclosporine. Monitor for increased toxic effects of etoposide if cyclosporine is initiated, the dose is increased, or it has been recently discontinued.

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