Interacting Drugs |
Diltiazem vs Protease Inhibitors |
Security Level |
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Mechanism |
Protease Inhibitors: May decrease the metabolism of Calcium Channel Blockers (Nondihydropyridine). Increased serum concentrations of the calcium channel blocker may increase risk of AV nodal blockade. |
Management |
Avoid concurrent use when possible. If this combination is used, monitor for evidence of toxicity. The manufacturer of atazanavir recommends a 50% dose reduction for diltiazem be considered. Use of ritonavir with bepridil is contraindicated. |
Diltiazem vs Protease Inhibitors
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Other Interactions of Protease Inhibitors
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