Diltiazem vs Budesonide (Systemic, Oral Inhalation)

Interacting Drugs
Diltiazem
vs
Budesonide (Systemic, Oral Inhalation)
Security Level
Moderate, Consider therapy modification
Mechanism
Budesonide (Systemic, Oral Inhalation): CYP3A4 Inhibitors (Moderate) may increase the serum concentration of Budesonide (Systemic, Oral Inhalation).
Management
Consider reducing the oral budesonide dose when used together with a CYP3A4 inhibitor. This interaction is likely less severe with orally inhaled budesonide. Monitor patients closely for signs/symptoms of corticosteroid excess.

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