Diclofenac and misoprostol vs Angiotensin II Receptor Blockers

Interacting Drugs
Diclofenac and misoprostol
vs
Angiotensin II Receptor Blockers
Security Level
Minor, Monitor Therapy
Mechanism
Angiotensin II Receptor Blockers: May enhance the adverse/toxic effect of Nonsteroidal Anti-Inflammatory Agents. Specifically, the combination may result in a significant decrease in renal function. Nonsteroidal Anti-Inflammatory Agents may diminish the therapeutic effect of Angiotensin II Receptor Blockers. The combination of these two agents may also significantly decrease glomerular filtration and renal function.
Management
Monitor therapy

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