Darunavir vs Colchicine

Interacting Drugs
Darunavir
vs
Colchicine
Security Level
Moderate, Consider therapy modification
Mechanism
Colchicine: P-glycoprotein/ABCB1 Inhibitors may increase the serum concentration of Colchicine. Colchicine distribution into certain tissues (e.g., brain) may also be increased.
Management
Colchicine is contraindicated in patients with impaired renal or hepatic function who are also receiving a p-glycoprotein inhibitor. In those with normal renal and hepatic function, reduce colchicine dose as directed.

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Darunavir vs Colchicine

Interacting Drugs
Darunavir
vs
Colchicine
Security Level
Moderate, Consider therapy modification
Mechanism
Colchicine: CYP3A4 Inhibitors (Strong) may increase the serum concentration of Colchicine.
Management
Colchicine is contraindicated in patients with impaired renal or hepatic function who are also receiving a strong CYP3A4 inhibitor. In those with normal renal and hepatic function, reduce colchicine dose as directed.

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