Clarithromycin vs Dabigatran Etexilate

Interacting Drugs
Clarithromycin
vs
Dabigatran Etexilate
Security Level
Moderate, Consider therapy modification
Mechanism
Dabigatran Etexilate: P-glycoprotein/ABCB1 Inhibitors may increase serum concentrations of the active metabolite(s) of Dabigatran Etexilate.
Management
Dabigatran dose reductions may be needed. According to Canadian labeling, dabigatran dose for prevention of venous thromboembolism post hip or knee replacement should be reduced to 150 mg/day in patients receiving amiodarone, verapamil, or quinidine.

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