Aspirin and diphenhydramine vs Vitamin K Antagonists (eg, warfarin)

Interacting Drugs
Aspirin and diphenhydramine
vs
Vitamin K Antagonists (eg, warfarin)
Security Level
Moderate, Consider therapy modification
Mechanism
Vitamin K Antagonists (eg, warfarin): Salicylates may enhance the anticoagulant effect of Vitamin K Antagonists.
Management
Consider therapy modification

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