Aluminum hydroxide, magnesium hydroxide, and simethicone vs Ketoconazole (Systemic)

Interacting Drugs
Aluminum hydroxide, magnesium hydroxide, and simethicone
vs
Ketoconazole (Systemic)
Security Level
Moderate, Consider therapy modification
Mechanism
Ketoconazole (Systemic): Antacids may decrease the serum concentration of Ketoconazole (Systemic).
Management
Administer oral ketoconazole at least 2 hours prior to use of any antacid product. Monitor patients closely for signs of inadequate clinical response to ketoconazole.

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