Ubidecarenone

Indications
 Oral
Heart failure
Adult: 50-150 mg daily in 2-3 divided doses.
Oral
Angina pectoris
Adult: 150-600 mg daily in divided doses.
Warnings / Precautions
 Avoid intense exercise during ubidecarenone therapy.
Adverse Reactions
 Gastric discomfort, anorexia, diarrhoea, nausea, skin rash, heart burn. Increase in LFT with doses >300 mg/day.
Drug Interactions
 Decreased serum levels with statins. Possible decrease in INR with warfarin.
See Below for More ubidecarenone Drug Interactions
Mechanism of Actions
 Ubidecarenone (also known as ubiquinone or coenzyme Q10) is a naturally occurring coenzyme structurally similar to vitamin K. It is involved in electron transport and energy production in the mitochondria. Although found in all human cells, it is present in high concentrations in the heart, kidney, liver and pancreas. It is also found in dietary supplements and has been tried in conditions associated with coenzyme deficiency and also as an adjunct in CV disorders including mild or moderate heart failure.
Absorption: Poor and slow GI absorption; absorption increased with high fat food.
Distribution: May undergo enterohepatic recycling. Plasma half life: 34 hr.
Metabolism: Extent of hepatic metabolism unknown.
Excretion: Mainly via bile, with >60% excreted unchanged in faeces.
Administration
 Should be taken with food. (Take after meals.)
ATC Classification
 C01EB09 - ubidecarenone ; Belongs to the class of other cardiac preparations.
Available As
  • Ubidecarenone 100 mg
  • Ubidecarenone 200 mg
  • Ubidecarenone 30 mg

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