Tropicamide

Indications
 Ophthalmic
Production of mydriasis
Adult: Instill 1-2 drops of a 0.5% solution 15-20 minutes before examination.
Ophthalmic
Production of cycloplegia
Adult: Instill 1-2 drops of a 1% solution repeated after 5 minutes. An additional drop may be admin after 20-30 minutes for prolonged effect.
Contraindications
 Hypersensitivity. Narrow-angle glaucoma or shallow anterior chamber.
Warnings / Precautions
 Elderly, children, pregnancy. Hypertension, hyperthyroidism, DM, cardiac disorders. To reduce systemic absorption, press on the lacrimal sac for 1-2 minutes following instillation. Do not drive or engage in hazardous activities and protect eyes from bright illumination when pupils are dilated. May fail to produce adequate cycloplegia in children.
Adverse Reactions
 Increased intraocular pressure, transient stinging, dry mouth, blurred vision, photophobia, tachycardia, headache, superficial punctate keratitis, systemic anticholinergic effects, severe CNS disturbances in children (rare).
Drug Interactions
 May antagonise effects of ophthalmic carbachol, pilocarpine, or cholinesterase inhibitors.
See Below for More tropicamide Drug Interactions
Mechanism of Actions
 Tropicamide is a tertiary amine antimuscarinic which causes relaxation of the sphincter muscle of the iris resulting in pupillary dilatation. It also causes paralysis of the ciliary muscle leading to loss of accommodation.
Onset: Mydriasis: 20-40 min; cycloplegia: 30 min.
Duration: Mydriasis: 6 hrs; cycloplegia: 6 hrs.
Storage Conditions
 Ophthalmic: Store between 15-30°C. Do not refrigerate.
ATC Classification
 S01FA06 - tropicamide ; Belongs to the class of anticholinergics used as mydriatics and cycloplegics.
Storage
 Ophthalmic: Store between 15-30°C. Do not refrigerate.
Available As
  • Tropicamide 0.8%
  • Tropicamide 0.8% w/v
  • Tropicamide 1%
  • Tropicamide 1% w/v

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