Salmeterol

Indications
 Inhalation
Chronic asthma, Chronic obstructive pulmonary disease
Adult: As metered-dose aerosol: 2 inhalations of 25 mcg bid up to 100 mcg bid. As dry powder inhalation: 50 mcg bid or 100 mcg bid if necessary.
Child: As metered-dose aerosol: ≥4 yr: 50 mcg bid.
Warnings / Precautions
 Pregnancy. Arrhythmias, hyperthyroidism, hypertension, DM, myocardial insufficiency, susceptibility to QT-interval prolongation. May cause paradoxical bronchospasm. Not to be used for treatment of acute bronchospasm or patients with deteriorating asthma. Monitor serum potassium concentrations in severe asthma.
Adverse Reactions
 Fine skeletal muscle tremor especially hands, tachycardia, palpitations, muscle cramps, headache, paradoxical bronchospasm, angioedema, urticaria, hypotension and collapse.
Overdose Reactions
 May result in exaggeration of adverse effects e.g. tachycardia and arrhythmia.
Drug Interactions
 Diuretics, corticosteroids and xanthines may augment hypokalaemia. Risk of severe hypertension when used with MAOIs, TCAs and other sympathomimetics. Increased susceptibility to cardiac arrhythmias caused by digoxin and other cardiac glycosides.
See Below for More salmeterol Drug Interactions
Mechanism of Actions
 Salmeterol is a direct-acting sympathomimetic which relaxes bronchial smooth muscle by its selective action on β2 receptors with little effect on heart rate.
Onset: Oral inhalation: 10-20 min.
Duration: 12 hr.
Absorption: Plasma concentrations are negligible after inhalation.
Distribution: About 96% bound to plasma proteins.
Metabolism: Hepatically hydroxylated.
Excretion: About 25% and 60% of the dose was eliminated in the urine and faeces respectively, over a period of 7 days.
Storage Conditions
 Inhalation: Store at 20-25°C.
ATC Classification
 R03AC12 - salmeterol ; Belongs to the class of adrenergic inhalants, selective beta-2-adrenoreceptor agonists. Used in the treatment of obstructive airway diseases.
Storage
 Inhalation: Store at 20-25°C.
Available As
  • Salmeterol 25 mcg
  • Salmeterol 50 mcg

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