Repaglinide

Indications
Oral
Type 2 diabetes mellitus
Adult: Usual initial dose: 0.5 mg, taken within 30 minutes of main meals. Initial doses of 1 or 2 mg may be used in patients who have had previous hypoglycaemic treatment. May adjust dose at intervals of 1-2 wk, up to 4 mg before meals. Max dose: 16 mg daily.
Hepatic impairment: May require longer intervals between dosage adjustments.
Contraindications
Diabetic ketoacidosis; severe hepatic impairment, type 1 diabetes; hypersensitivity. Lactation.
Warnings / Precautions
Myocardial infarction, coma, trauma during surgery, elderly, malnourished and debilitated patients. Hepatic or severe renal impairment. Pregnancy.
Adverse Reactions
Hypoglycaemia, nausea, diarrhoea, constipation, vomiting, dyspepsia, arthralgia, sinusitis, rhinitis, back pain; rash, pruritus, urticaria; visual disturbances.
Overdose Reactions
Severe hypoglycaemic reactions with coma, seizure and other neurological impairment may occur.
Drug Interactions
Cytochrome P450 3A4 inducers eg. rifampicin, barbiturates and carbamazepine may increase repaglinide metabolism. NSAIDs and other highly protein bound drugs eg, salicylates, sulphonamides, phenylbutazone, oral anticoagulants and hydantoins may potentiate action of repaglinide. Ketoconazole, fluconazole, itraconazole and erythromycin may increase plasma conc of repaglinide. Antagonistic effect with drugs causing hyperglycaemia. Concurrent use with gemfibrozil may lead to enhanced and prolonged blood glucose lowering effect.
Potentially Fatal: Increased risk of myocardial infarction when used with isophane insulin.
See Below for More repaglinide Drug Interactions
Food Interactions
Absorption may be affected when given with food.
Mechanism of Actions
Repaglinide stimulates release of insulin from pancreatic β-cells by inhibiting K efflux via closure of ATP regulated K channels. This results in depolarization of the cell and opening of voltage-dependent Ca channels, which increases influx of Ca into the beta cells and causes release of insulin.
Absorption: Rapid and complete; peak plasma concentrations after 1 hr (oral).
Distribution: Protein-binding: >98%.
Metabolism: Completely metabolised by oxidative biotransformation and direct conjugation with glucuronic acid.
Excretion: Urine (about 8%); faeces (90%).
Administration
Should be taken with food. (Usually taken w/in 15 min of the meal but time may vary from immediately before to 30 min before the meal.)
Storage Conditions
Oral: Store below 25°C. Protect from moisture.
ATC Classification
A10BX02 - repaglinide ; Belongs to the class of other blood glucose lowering drugs excluding insulins. Used in the management of diabetes.
Storage
Oral: Store below 25°C. Protect from moisture.
Available As
  • Repaglinide 0.5 mg
  • Repaglinide 1 mg
  • Repaglinide 2 mg
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    Repaglinide Containing Brands

    Click on Prescription information to see Indications ( Uses ), Contraindications, Prescription information of respective Constituents.

    Brand Name Manufacturer Unit/Price Package unit/Price Constituents/Unit
    Tablet Page (0.5 mg) Diabetes (Orchid Chemicals & Pharmaceuticals Ltd.) 1 Tablet
    ₹ 2.10
    10 Tablet
    ₹ 21.00
  • More Information Repaglinide 0.5 mg
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    Tablet Page (1 mg) Diabetes (Orchid Chemicals & Pharmaceuticals Ltd.) 1 Tablet
    ₹ 4.18
    10 Tablet
    ₹ 41.80
  • More Information Repaglinide 1 mg
  • See Brands having above combination
    Tablet Rapilin (0.5 mg) Sun Pharmaceutical Industries Ltd. 1 Tablet
    ₹ 3.40
    10 Tablet
    ₹ 34.00
  • More Information Repaglinide 0.5 mg
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    Tablet Q Repa (0.5 mg) Q Check Speciality Care 1 Tablet
    ₹ 2.70
    10 Tablet
    ₹ 27.00
  • More Information Repaglinide 0.5 mg
  • See Brands having above combination
    Tablet Q Repa (1 mg) Q Check Speciality Care 1 Tablet
    ₹ 4.70
    10 Tablet
    ₹ 47.00
  • More Information Repaglinide 1 mg
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    Tablet Restrict (0.5 mg) East West Pharma 1 Tablet
    ₹ 4.84
    10 Tablet
    ₹ 48.40
  • More Information Repaglinide 0.5 mg
  • See Brands having above combination
    Tablet Repide (0.5 mg) Wallace Pharmaceuticals Ltd. 1 Tablet
    ₹ 2.90
    10 Tablet
    ₹ 29.00
  • More Information Repaglinide 0.5 mg
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    Tablet Repa (0.5 mg) Mano (Orchid Chemicals & Pharmaceuticals Ltd.) 1 Tablet
    ₹ 1.99
    10 Tablet
    ₹ 19.90
  • More Information Repaglinide 0.5 mg
  • See Brands having above combination
    Tablet Repa (1 mg) Mano (Orchid Chemicals & Pharmaceuticals Ltd.) 1 Tablet
    ₹ 3.90
    10 Tablet
    ₹ 39.00
  • More Information Repaglinide 1 mg
  • See Brands having above combination
    Tablet Regan (0.5 mg) Stancare (Ranbaxy Laboratories Ltd) 1 Tablet
    ₹ 2.90
    10 Tablet
    ₹ 29.00
  • More Information Repaglinide 0.5 mg
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    Repaglinide is used in following diseases

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    Drug - Drug Interactions of Repaglinide
    Interaction
    Minor, Monitor Therapy Repaglinide vs Hypoglycemic Agents
    Minor, Monitor Therapy Repaglinide vs Herbs (Hypoglycemic Properties)
    Minor, Monitor Therapy Repaglinide vs Herbs (CYP3A4 Inducers)
    Major, Avoid combination Repaglinide vs Gemfibrozil
    Moderate, Consider therapy modification Repaglinide vs Eltrombopag
    Minor, Monitor Therapy Repaglinide vs Deferasirox
    Minor, Monitor Therapy Repaglinide vs Dasatinib
    Moderate, Consider therapy modification Repaglinide vs CYP3A4 Inhibitors (Strong)
    Minor, Monitor Therapy Repaglinide vs CYP3A4 Inhibitors (Moderate)
    Minor, Monitor Therapy Repaglinide vs CYP3A4 Inducers (Strong)
    Pages: 1 2 3 4 5 6 7 8 Next