Piribedil

Indications	Oral As monotherapy in Parkinson's disease *Adult:* Monotherapy: 150-250 mg daily in divided doses. In combination with levodopa therapy: 80-140 mg daily. Oral Circulatory disorders *Adult:* 50 mg daily or 100 mg daily in 2 divided doses for severe cases.
Contraindications	Hypersensitivity, CV collapse, acute myocardial infarction, uncontrolled hypertension, pregnancy.
Warnings / Precautions	Raynaud's syndrome, history of psychosis, renal impairment. May cause hypotension in the first few days of treatment. Regular ophthalmological monitoring is recommended. Lactation.
Adverse Reactions	Nausea, vomiting, dizziness, confusion, drowsiness, hypothermia, dyskinesias, occasional changes in liver function. Raynaud's syndrome or digital vasospasm, leg cramps.
Drug Interactions	Clonidine and dopamine antagonists eg, phenothiazines and haloperidol may antagonise effects of piribedil. See Below for More piribedil Drug Interactions
Mechanism of Actions	Piribedil is a non-ergot dopamine D₂ agonist that stimulates cerebral and peripheral dopamine receptors and corrects dopamine deficiency. It is used largely, as an adjunct to levodopa therapy in the treatment of Parkinson's disease.
Administration	Should be taken with food. (Take at the end of a main meal.)
ATC Classification	N04BC08 - piribedil ; Belongs to the class of dopamine agonists. Used in the management of Parkinson's disease.
Available As	Piribedil 50 mg

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